Italy has extended its emergency coronavirus measures, which include travel restrictions and a ban on public gatherings, to the entire country.
On Monday, Prime Minister Giuseppe Conte ordered people to stay home and seek permission for essential travel.
He said the measures were designed to protect the most vulnerable. "There is no more time," he said in a TV address.
Italy's coronavirus death toll jumped from 366 to 463 on Monday. It is the worst-hit country after China.
The number of confirmed infection also increased by 24% from Sunday, official figures showed.
Cases of the virus have been confirmed in all 20 Italian regions.
What did Mr Conte say?
Mr Conte said the best thing was for people to stay at home. "We're having an important growth in infection... and of deaths," he said in an evening address.
"The whole of Italy will become a protected zone," he added.
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We all must give something up for the good of Italy. We have to do it now.
"This is why I decided to adopt even more strong and severe measures to contain the advance... and protect the health of all citizens."
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In an earlier interview with La Repubblica newspaper, Mr Conte said of the outbreak: "I have been thinking about the old speeches of [Winston] Churchill - it is our darkest hour, but we will make it".
What are the restrictions?
Mr Conte described the measures as "I stay home" - with people forbidden to gather in public. "No more nightlife; we can't allow this anymore since they are occasions for contagion," he said.
All sporting events - including football matches - are suspended nationwide. Schools and universities will remain closed until 3 April.
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The government said only those with a valid work or family reason that cannot be postponed will be allowed to travel.
Passengers departing on flights will have to justify themselves, as will all those who arrive by plane.
There are controls at train stations to check the temperatures of passengers. Cruise ships are also forbidden to dock at various ports.
How have people reacted?
Earlier on Monday, seven inmates died amid riots at prisons across the country after authorities suspended all visits as part of attempts to control the spread of the disease.
The trouble began in the northern city of Modena at the Sant'Anna prison.
It is thought that at least two of the dead lost their lives to drug overdoses after they raided a prison hospital for the heroin substitute methadone.
At San Vittore prison in Milan, detainees set fire to a cell block, then climbed onto the roof through windows and started waving banners, officials said.
At a prison in the southern city of Foggia, dozens of inmates broke out of the building during protests. Many were quickly recaptured, Italy's Ansa news agency reported. Nine are still missing.
There were also riots at other prisons in northern Italy and at facilities in Naples and Rome.
How about the rest of the world?
The number of infections worldwide is now more than 111,000, with about 3,890 deaths.
Everyone arriving in Israel will be required to self-quarantine for 14 days, Prime Minister Benjamin Netanyahu announced.
Iran has reported 43 new deaths related to the disease in the past 24 hours. At least 237 people have died and 7,161 have been infected across the country since mid-February, although the real figures are believed to be far higher.
China, which has recorded the highest number of fatalities, reported just 40 new cases of Covid-19, the lowest since 20 January.
Although this indicates that the spread there is slowing, senior officials warned against reducing vigilance.
In other developments:
The World Health Organization (WHO) has warned that the threat of a pandemic is "very real"
Canada has confirmed the first death related to the virus - an elderly male patient in a care home in Vancouver, British Columbia
In France, Culture Minister Franck Riester has become the first member of the government to be infected with the virus. His team said he had spent several days of the past week in parliament, where a number of other cases have been confirmed
In the US, the number of confirmed cases now exceeds 500
A cruise ship carrying thousands of people who were stranded for days due to a coronavirus outbreak has docked at the port of Oakland, near San Francisco
Shares around the world had their worst day since the financial crisis amid concerns about the economic cost of the outbreak.